Well, of course, taking a Guanche perspective...
1402: Arrival of Jean de Béthencourt and Gadifer de la Salle to the island of Lanzarote. This should have been a dire warning to the Tenerife crowd, and it was...
But even so...
November 14-15, 1494: Battle of Aguere - pretty frigging disastrous if you were Guanche.
December 25, 1494: (Christmas Day - nice) Second Battle of Acentejo. Game Over.
Night-night, natives. It's the great nations of Europe... comin' thru.